A health concern regarding the protein corona, aggregation and disaggregation
نویسندگان
چکیده
منابع مشابه
Small heat shock proteins in protein aggregation and disaggregation
Many factors leading to unfolding and misfolding of proteins eventually result in protein aggregation. Stress imposed by high temperature was one of the first aggregation-inducing factors studied, and remains one of the main models in this field. The cell needs chaperone proteins to control and counteract the aggregation process. Elimination of aggregates can be achieved by solubilization of ag...
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The chaperone protein network controls both initial protein folding and subsequent maintenance of proteins in the cell. Although the native structure of a protein is principally encoded in its amino acid sequence, the process of folding in vivo very often requires the assistance of molecular chaperones. Chaperones also play a role in a posttranslational quality control system and thus are requi...
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Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants in biotherapeutics formulations, typically non-ionic polymeric ether surfactants. The most commonly used examples are Tween 20 (Polysorbate 20...
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The paper presents some modifications of two-level methods for computing stationary probability distribution vector of large discrete time Markov chains. The approach considered is an iterative aggregation disaggregation method. Two types of permuting the events are considered in order to improve the convergence.
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2019
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2019.02.012